Neutralization kinetics studies with type SAT 2 foot-and-mouth disease virus strains:II. Antigenic differentiation of vaccine strains

A comparison of homologous and heterologous rates of neutralization demonstrated that antigenic relationships of foot-and-mouth disease virus strains could be differentiated quantitatively by the kinetics of neutralization method described previously (Rweyemamu, Booth & Pay, 1977). Conventional...

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Bibliographic Details
Published in:The Journal of hygiene 1977-06, Vol.78 (3), p.429-438
Main Authors: Rweyemamu, M. M., Booth, J. C., Parry, N., Pay, T. W. F.
Format: Article
Language:English
Subjects:
animal diseases
animal health
Antibodies
Antiserum
Complement fixation tests
Foot and mouth disease
Foot and mouth disease virus
Kinetics
Neutralization tests
Standardized tests
Vaccination
Viruses
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Summary:A comparison of homologous and heterologous rates of neutralization demonstrated that antigenic relationships of foot-and-mouth disease virus strains could be differentiated quantitatively by the kinetics of neutralization method described previously (Rweyemamu, Booth & Pay, 1977). Conventional formulae for r, R and D values could be applied to results obtained by this method. It was demonstrated that results analysed this way gave R values which were similar to those obtained with other neutralization test methods but which were generally smaller than those obtained with complement fixation test results. It was demonstrated that there were wide differences between the vaccine strains tested as demonstrated by R value relationships. An examination of r values, however, demonstrated that antisera to the Moz 1/70 strain were highly reactive with most of the virus strains from Central and Southern Africa. The selection of FMD virus strains with a wide serological range for vaccine production is discussed.
ISSN:0022-1724
2396-8184
DOI:10.1017/S0022172400056321