Permeability changes in the egg-shell of hookworms during development and eclosion

The development and hatching of Ancylostoma ceylanicum and Ancylostoma tubaeforme eggs in a range of potentially inimical solutions has been examined using time-lapse video micro-recording techniques. In all compounds tested the larvae developed to the active pretzel stage. The inception of activity...

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Bibliographic Details
Published in:Parasitology 1986-12, Vol.93 (3), p.547-557
Main Author: Matthews, B. E.
Format: Article
Language:English
Subjects:
Acridine Orange - metabolism
Ancylostoma - drug effects
Ancylostoma - physiology
Ancylostoma ceylanicum
Ancylostoma tubaeforme
Animals
Biochemistry. Physiology. Immunology. Molecular biology
Biological and medical sciences
development
Diethylcarbamazine - pharmacology
Fundamental and applied biological sciences. Psychology
hatching
Invertebrates
Larva - drug effects
Larva - metabolism
Morantel - pharmacology
Nemathelminthia. Plathelmintha
ova
Ovum - drug effects
Ovum - metabolism
Permeability
Physiology. Development
Piperazines - pharmacology
Videotape Recording
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Summary:The development and hatching of Ancylostoma ceylanicum and Ancylostoma tubaeforme eggs in a range of potentially inimical solutions has been examined using time-lapse video micro-recording techniques. In all compounds tested the larvae developed to the active pretzel stage. The inception of activity resulted in an increase in shell permeability to water and small molecules. In anthelmintics of molecular weight (Mr) 400 development continued normally until about the time that control eggs hatched, when there was a marked decrease in larval activity and eclosion did not occur. The addition of a low Mr surface-active agent potentiated the effect of the anthelmintic and caused larval activity to be lost earlier. The calcium inhibitor lanthanum chloride affected larval development rather than eclosion. Large Mr compounds did not affect either development or hatching and the results suggest that the egg-shell may act as a form of sieve, allowing the essential oxygen to reach the developing larva while excluding large potentially dangerous molecules. No appreciable differences were found between the two species of hookworm examined.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182000081257