The current status of antiparasite chemotherapy

Currently used antiparasitic drugs, including benzimidazoles, nitroimidazoles, avermectins, polyene ionophores, hydroxynaphthoquinones and sesquiterpene lactones, were identified through the empirical route to drug discovery. The modern rational approach to drug design is focused upon the structure...

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Bibliographic Details
Published in:Parasitology 1997-06, Vol.114 (7), p.3-15
Main Author: CROFT, S. L.
Format: Article
Language:English
Subjects:
Animals
Anthelmintics - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiparasitic Agents - pharmacology
Antiprotozoal Agents - pharmacology
Biological and medical sciences
Coccidiosis - drug therapy
Drug Design
Drug Industry - trends
Helminthiasis - drug therapy
Medical sciences
Microsporidiosis - drug therapy
Pharmacology. Drug treatments
Protozoan Infections - drug therapy
Citations: Items that cite this one
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Summary:Currently used antiparasitic drugs, including benzimidazoles, nitroimidazoles, avermectins, polyene ionophores, hydroxynaphthoquinones and sesquiterpene lactones, were identified through the empirical route to drug discovery. The modern rational approach to drug design is focused upon the structure and function of biochemical and molecular targets. The requisite pharmacological properties for new anti-parasite drugs should not be ignored in this process.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182097001182