Multicompartmental analysis of amino acids: 1. Preliminary data on concentrations, fluxes, and flow constants of tryptophan in affective illness

The study of tryptophan metabolism using compartmental analysis suggested differences between males and females, and between control subjects and patients with affective illness, patients treated with tricyclic drugs, and those established on lithium therapy. The total mass of tryptophan in the body...

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Bibliographic Details
Published in:Psychological medicine 1975-05, Vol.5 (2), p.206-213
Main Authors: Shaw, David M., Johnson, Anthony L., Tidmarsh, Simon F., Macsweeney, David A., Hewland, H. Robyn, Woolcock, Norman E.
Format: Article
Language:English
Subjects:
Preliminary Communication
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Summary:The study of tryptophan metabolism using compartmental analysis suggested differences between males and females, and between control subjects and patients with affective illness, patients treated with tricyclic drugs, and those established on lithium therapy. The total mass of tryptophan in the body may be reduced in people prone to affective disorder, and in depressed patients (ill and well) turnover of tryptophan seemed to be reduced. The reduction of concentration of tryptophan in compartment S2 in affective illness could affect protein synthesis.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291700056476