Multicompartmental analysis of amino acids: 1. Preliminary data on concentrations, fluxes, and flow constants of tryptophan in affective illness

The study of tryptophan metabolism using compartmental analysis suggested differences between males and females, and between control subjects and patients with affective illness, patients treated with tricyclic drugs, and those established on lithium therapy. The total mass of tryptophan in the body...

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Published in:Psychological medicine 1975-05, Vol.5 (2), p.206-213
Main Authors: Shaw, David M., Johnson, Anthony L., Tidmarsh, Simon F., Macsweeney, David A., Hewland, H. Robyn, Woolcock, Norman E.
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Language:English
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Preliminary Communication
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creator Shaw, David M.
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description The study of tryptophan metabolism using compartmental analysis suggested differences between males and females, and between control subjects and patients with affective illness, patients treated with tricyclic drugs, and those established on lithium therapy. The total mass of tryptophan in the body may be reduced in people prone to affective disorder, and in depressed patients (ill and well) turnover of tryptophan seemed to be reduced. The reduction of concentration of tryptophan in compartment S2 in affective illness could affect protein synthesis.
doi_str_mv 10.1017/S0033291700056476
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source KB+ Cambridge University Press: JISC Collections:Full Collection Digital Archives (STM and HSS)
subjects Preliminary Communication
title Multicompartmental analysis of amino acids: 1. Preliminary data on concentrations, fluxes, and flow constants of tryptophan in affective illness
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