Analysis of a Reactive Dimethylenedihydrothiophene in Methylene Chloride by Low-Temperature Atmospheric Pressure Ionization Mass Spectrometry

The use of atmospheric pressure ionization at −78 °C for the analysis of a thermally unstable compound, 2,5-dimethylene-2,5-dihydrothiophene, dissolved in methylene chloride is demonstrated with a home-built low-temperature electrospray source connected to a quadruple mass analyzer. To prevent the a...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 1996-03, Vol.68 (6), p.1062-1066
Main Authors: Shiea, Jentaie, Wang, Wen-Shyang, Wang, Chin-Hsiung, Chen, Ping-Shu, Chou, Chin-Hsing
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Exact sciences and technology
Spectrometric and optical methods
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Summary:The use of atmospheric pressure ionization at −78 °C for the analysis of a thermally unstable compound, 2,5-dimethylene-2,5-dihydrothiophene, dissolved in methylene chloride is demonstrated with a home-built low-temperature electrospray source connected to a quadruple mass analyzer. To prevent the analyte molecule from polymerizing at elevated temperatures, the sample solution was maintained at −78 °C in the dry-ice-cooled sample injection and sample loop units. The solution was delivered to the spray needle by compressing the nitrogen gas in a syringe which was connected to the sample loop by a Teflon tube. At such low temperature, a strong ion signal was obtained from the analyte molecule as a result of corona discharge ionization.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac951037i