Framework-Induced Electrochemiluminescence Enhancement of an AIEgen-Based MOF Coupled with Heterostructured TiO 2 @Ag NPs as an Efficient Coreaction Accelerator for Sensitive Biosensing

In conventional metal-organic framework (MOF) luminophore-involved electrochemiluminescence (ECL) systems, the aggregation-caused quenching commonly exists for the organic luminescent ligands, limiting the ECL efficiency and detection sensitivity. Herein, by employing the aggregation-induced emissio...

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Published in:Analytical chemistry (Washington) 2024-09, Vol.96 (37), p.14926
Main Authors: Du, Yu, Li, Faying, Ren, Xiang, Wu, Dan, Ma, Hongmin, Kuang, Xuan, Li, Jingshuai, Feng, Rui, Wei, Qin
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analysis
Aptamers, Nucleotide - chemistry
Biosensing Techniques - methods
Electrochemical Techniques
Limit of Detection
Luminescent Measurements
Metal Nanoparticles - chemistry
Metal-Organic Frameworks - chemistry
Silver - chemistry
Titanium - chemistry
Zirconium - chemistry
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Summary:In conventional metal-organic framework (MOF) luminophore-involved electrochemiluminescence (ECL) systems, the aggregation-caused quenching commonly exists for the organic luminescent ligands, limiting the ECL efficiency and detection sensitivity. Herein, by employing the aggregation-induced emission luminogen (AIEgen) 1,1,2,2-tetra(4-carboxylbiphenyl)ethylene (H TCBPE) as a ligand, one high-efficiency ECL emitter (Zr-MOF) was synthesized through a simple hydrothermal reaction. Compared with H TCBPE monomers and their aggregates, the resultant Zr-MOF possesses the strongest ECL emission, which is mainly attributed to the framework-induced ECL enhancement. Specifically, the heterostructure was prepared by the deposition of silver nanoparticles on TiO microflowers and utilized as an efficient coreaction accelerator. Remarkably, the formative heterojunction can increase the interfacial charge transfer efficiency and promote the carrier separation, facilitating the oxidation of coreactant tripropylamine. In this way, a novel aptamer-mediated ECL sensing platform is constructed, achieving the sensitive analysis of adenosine triphosphate with a low detection limit of 0.17 nM. As a proof-of-concept study, this work may enlighten the rational design of new-type MOF-based ECL materials and expand the application scope of the ECL technology.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.4c02991