Switchable Nanochannel Biosensor for H 2 S Detection Based on an Azide Reduction Reaction Controlled BSA Aggregation

Hydrogen sulfide (H S) is the third endogenous gaseous signal molecule in organisms that can directly increase the salt tolerance of plants by closing the K channel. Inspired by the important role of H S in nature, we have designed a H S-responsive artificial nanochannel biosensor based on an azide...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2019-05, Vol.91 (9), p.6149-6154
Main Authors: Zhang, Ruiping, Chen, Xiaoya, Sun, Zhongyue, Chen, Sen, Gao, Jing, Sun, Yao, Li, Haibing
Format: Article
Language:English
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Summary:Hydrogen sulfide (H S) is the third endogenous gaseous signal molecule in organisms that can directly increase the salt tolerance of plants by closing the K channel. Inspired by the important role of H S in nature, we have designed a H S-responsive artificial nanochannel biosensor based on an azide reduction reaction strategy. This biomimetic device demonstrates an excellent H S selective response owing to specific azide reduction by H S inducing BSA aggregation on the channel with a high ion gating ratio. Furthermore, this H S-responsive biosensor shows excellent reversibility and stability and a fast response rate, which will help us better understand the synergistic effect of H S messengers in the ion channels of living organisms.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.9b00752