Zwitterionic Cocrystals of Flavonoids and Proline: Solid-State Characterization, Pharmaceutical Properties, and Pharmacokinetic Performance

We utilized the concepts of crystal engineering to acquire cocrystals of d/l-proline with a variety of flavonoids and further evaluated the impact on solubility and pharmacokinetic of flavonoids. We have synthesized and characterized six d/l-proline cocrystals with flavonoids and their single crysta...

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Bibliographic Details
Published in:Crystal growth & design 2016-04, Vol.16 (4), p.2348-2356
Main Authors: He, Hongyan, Huang, Ying, Zhang, Qi, Wang, Jian-Rong, Mei, Xuefeng
Format: Article
Language:English
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Summary:We utilized the concepts of crystal engineering to acquire cocrystals of d/l-proline with a variety of flavonoids and further evaluated the impact on solubility and pharmacokinetic of flavonoids. We have synthesized and characterized six d/l-proline cocrystals with flavonoids and their single crystal structures were revealed. The powder dissolution profiles were determined and the pharmacokinetic properties for Kae-l-Pro were analyzed and compared with the corresponding physical mixture. d/l-Proline was found to be a suitable coformer for a variety of structural similar flavonoids. This study may offer an alternative approach for the development of these widely used flavonoids.
ISSN:1528-7483
1528-7505
DOI:10.1021/acs.cgd.6b00142