Face-Discriminating Dissolution Kinetics of Furosemide Single Crystals: In Situ Three-Dimensional Multi-Microscopy and Modeling

A versatile in situ multi-microscopy approach to study the dissolution kinetics of single crystals is described, using the loop diuretic drug furosemide as a testbed to demonstrate the utility of the approach. Using optical microscopy and scanning ion-conductance microscopy in combination, the disso...

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Bibliographic Details
Published in:Crystal growth & design 2016-08, Vol.16 (8), p.4421-4429
Main Authors: Adobes-Vidal, Maria, Maddar, Faduma M, Momotenko, Dmitry, Hughes, Leslie P, Wren, Stephen A. C, Poloni, Laura N, Ward, Michael D, Unwin, Patrick R
Format: Article
Language:English
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Summary:A versatile in situ multi-microscopy approach to study the dissolution kinetics of single crystals is described, using the loop diuretic drug furosemide as a testbed to demonstrate the utility of the approach. Using optical microscopy and scanning ion-conductance microscopy in combination, the dissolution rate of individual crystallographically independent crystal faces can be measured quantitatively while providing a direct visualization of the evolution of crystal morphology in real time in three dimensions. Finite element method models using experimental data enables quantitative analysis of dissolution fluxes for individual faces and determination of the limiting processmass transport or interfacial kineticsthat regulates dissolution. A key feature of the approach is that isolated crystals (typically
ISSN:1528-7483
1528-7505
DOI:10.1021/acs.cgd.6b00543