Spontaneous Solid-State Cocrystallization of Caffeine and Urea

The cocrystallization of caffeine and urea was monitored and analyzed using infrared spectroscopy, Raman microscopy, scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction. The caffeine–urea cocrystal was shown to form spontaneously over several weeks under low energy...

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Bibliographic Details
Published in:Crystal growth & design 2020-02, Vol.20 (2), p.736-745
Main Authors: MacFhionnghaile, Pól, Crowley, Clare M, McArdle, Patrick, Erxleben, Andrea
Format: Article
Language:English
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Summary:The cocrystallization of caffeine and urea was monitored and analyzed using infrared spectroscopy, Raman microscopy, scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction. The caffeine–urea cocrystal was shown to form spontaneously over several weeks under low energy mixing of the solids at room temperature and low relative humidity (
ISSN:1528-7483
1528-7505
DOI:10.1021/acs.cgd.9b01152