Role of Hydrazine-Related Chemicals in Cancer and Neurodegenerative Disease

Hydrazine-related chemicals (HRCs) with carcinogenic and neurotoxic potential are found in certain mushrooms and plants used for food and in products employed in various industries, including aerospace. Their propensity to induce DNA damage (mostly O 6-, N7- and 8-oxo-guanine lesions) resulting in m...

Full description

Saved in:
Bibliographic Details
Published in:Chemical research in toxicology 2021-09, Vol.34 (9), p.1953-1969
Main Authors: Spencer, Peter S, Kisby, Glen E
Format: Article
Language:English
Subjects:
Animals
Carcinogens - toxicity
DNA Damage - drug effects
DNA Repair - physiology
Gene Expression Regulation - physiology
Humans
Hydrazines - toxicity
Liver - drug effects
Neoplasms - complications
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - physiopathology
Neurodegenerative Diseases - complications
Neurodegenerative Diseases - etiology
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - physiopathology
Neurons - drug effects
Neurons - metabolism
Neurotoxins - toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hydrazine-related chemicals (HRCs) with carcinogenic and neurotoxic potential are found in certain mushrooms and plants used for food and in products employed in various industries, including aerospace. Their propensity to induce DNA damage (mostly O 6-, N7- and 8-oxo-guanine lesions) resulting in multiple downstream effects is linked with both cancer and neurological disease. For cycling cells, unrepaired DNA damage leads to mutation and uncontrolled mitosis. By contrast, postmitotic neurons attempt to re-enter the cell cycle but undergo apoptosis or nonapoptotic cell death. Biomarkers of exposure to HRCs can be used to explore whether these substances are risk factors for sporadic amyotrophic laterals sclerosis and other noninherited neurodegenerative diseases, which is the focus of this paper.
ISSN:0893-228X
1520-5010
DOI:10.1021/acs.chemrestox.1c00150