Ratio of Propylene Glycol to Glycerol in E-Cigarette Reservoirs Is Unchanged by Vaping As Determined by 1 H NMR Spectroscopy

E-cigarette liquids (e-liquids) contain propylene glycol (PG) and/or glycerol (GL) to deliver flavorants/nicotine. It has recently been suggested that the PG:GL ratio in e-cigarette reservoirs changes during vaping, leaving almost entirely GL after aerosolizing much of a 30:70 PG:GL mixture. To eval...

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Bibliographic Details
Published in:Chemical research in toxicology 2021-08, Vol.34 (8), p.1846-1849
Main Authors: Kerber, Paul J, Duell, Anna K, Peyton, David H
Format: Article
Language:English
Subjects:
Aerosols - analysis
Electronic Nicotine Delivery Systems
Flavoring Agents - analysis
Glycerol - analysis
Humans
Magnetic Resonance Spectroscopy
Propylene Glycol - analysis
Vaping
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Summary:E-cigarette liquids (e-liquids) contain propylene glycol (PG) and/or glycerol (GL) to deliver flavorants/nicotine. It has recently been suggested that the PG:GL ratio in e-cigarette reservoirs changes during vaping, leaving almost entirely GL after aerosolizing much of a 30:70 PG:GL mixture. To evaluate this directly, we analyzed e-liquids from e-cigarettes before and after aerosolization using 4 different coils, and aerosol samples generated using high and low e-liquid levels. The PG:GL ratios of initial and final e-liquids and aerosol samples were comparable. This is important because a large change in e-liquid composition could substantially alter the aerosol profile during a vaping session.
ISSN:0893-228X
1520-5010
DOI:10.1021/acs.chemrestox.1c00208