Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation

Contamination of food/feedstuffs by mycotoxins is a serious problem worldwide, causing severe economic losses and serious health problems in animals/humans. Deoxynivalenol (DON) is a major mycotoxin contaminant and is known to impair intestinal barrier function. Grapes and red wine are rich in polyp...

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Bibliographic Details
Published in:Chemical research in toxicology 2016-05, Vol.29 (5), p.823-833
Main Authors: Ling, Ka-Ho, Wan, Murphy Lam Yim, El-Nezami, Hani, Wang, Mingfu
Format: Article
Language:English
Subjects:
Animals
Bacterial Translocation - drug effects
Cell Line
Cytokines - metabolism
Inflammation Mediators - metabolism
Intestines - drug effects
Intestines - metabolism
Intestines - physiopathology
Stilbenes - pharmacology
Swine
Trichothecenes - toxicity
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Summary:Contamination of food/feedstuffs by mycotoxins is a serious problem worldwide, causing severe economic losses and serious health problems in animals/humans. Deoxynivalenol (DON) is a major mycotoxin contaminant and is known to impair intestinal barrier function. Grapes and red wine are rich in polyphenols, such as resveratrol (RES), which has striking antioxidant and anti-inflammatory activities. RES is a food-derived component; therefore, it may be simultaneously present with DON in the gastrointestinal tract. The aim of this study was to explore in vitro protective effects of RES against DON-induced intestinal damage. The results showed that RES could protect DON-induced bacteria translocation because of enhanced of intestinal barrier function by restoring the DON-induced decrease in transepithelial electrical resistance and increase in paracellular permeability. Further mechanistic studies demonstrated that RES protects against DON-induced barrier dysfunction by promoting the assembly of claudin-4 in the tight junction complex. This is probably mediated through modulation of IL-6 and IL-8 secretion via mitogen-activated protein kinase-dependent pathways. Our results imply that RES can protect against DON-induced intestinal damage and that RES may be used as a novel dietary intervention strategy to reduce DON toxicity in animals/humans.
ISSN:0893-228X
1520-5010
DOI:10.1021/acs.chemrestox.6b00001