Residence Time Distribution Characterization and Proof-of-Concept of a Novel Stacked 7‑Stage Continuous Crystallizer Cascade with Diaphragm-Driven Slurry Transfer

Process developers in the pharmaceutical industry lack readily deployable, standardized, off-the-shelf continuous crystallizers (300 μm. Finally, a proof-of-concept continuous antisolvent crystallization of glycine demonstrates the TWC’s capability to produce high-quality crystals continuously, prov...

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Bibliographic Details
Published in:Industrial & engineering chemistry research 2024-10, Vol.63 (42), p.18199-18211
Main Authors: Aprile, Giovanni, Pandit, Ajinkya V., Albertazzi, Jody, Vetter, Thomas, Viano, Robert, Milani, Lorenzo, Adamo, Andrea, Myerson, Allan S., Stelzer, Torsten
Format: Article
Language:English
Subjects:
General Research
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Summary:Process developers in the pharmaceutical industry lack readily deployable, standardized, off-the-shelf continuous crystallizers (300 μm. Finally, a proof-of-concept continuous antisolvent crystallization of glycine demonstrates the TWC’s capability to produce high-quality crystals continuously, proving its functional and robust operation.
ISSN:0888-5885
1520-5045
DOI:10.1021/acs.iecr.4c02153