Lysosome-Targeted Chemotherapeutics: Half-Sandwich Ruthenium(II) Complexes That Are Selectively Toxic to Cancer Cells

Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward normal cells. Confocal microscopy was employed for...

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Bibliographic Details
Published in:Inorganic chemistry 2018-09, Vol.57 (17), p.10498-10502
Main Authors: Tian, Zhenzhen, Li, Juanjuan, Zhang, Shumiao, Xu, Zhishan, Yang, Yuliang, Kong, Deliang, Zhang, Hairong, Ge, Xingxing, Zhang, Junming, Liu, Zhe
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Binding Sites
Cell Line
Cell Line, Tumor
Coordination Complexes - pharmacology
Drug Delivery Systems
Humans
Inhibitory Concentration 50
Lysosomes - drug effects
Molecular Structure
Ruthenium - pharmacology
Serum Albumin, Bovine - drug effects
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Description
Summary:Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward normal cells. Confocal microscopy was employed for the first time to determine the cellular localization of the half-sandwich Ru complex.
ISSN:0020-1669
1520-510X
DOI:10.1021/acs.inorgchem.8b01944