Antiaflatoxigenic and Antimicrobial Activities of Schiff Bases of 2‑Hydroxy-4-methoxybenzaldehyde, Cinnamaldehyde, and Similar Aldehydes

2-Hydroxy-4-methoxybenzaldehyde (HMBA) is a nontoxic phenolic flavor from dietary source Decalipus hamiltonii and Hemidesmus indicus. HMBA is an excellent antimicrobial agent with additional antiaflatoxigenic potency. On the other hand, cinnamaldehyde from cinnamon is a widely employed flavor with s...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2017-10, Vol.65 (40), p.8773-8778
Main Authors: Harohally, Nanishankar V, Cherita, Chris, Bhatt, Praveena, Anu Appaiah, K. A
Format: Article
Language:English
Subjects:
Acrolein - analogs & derivatives
Acrolein - chemistry
Acrolein - pharmacology
Aflatoxin B1 - metabolism
Aldehydes - chemistry
Aldehydes - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Apocynaceae - chemistry
Aspergillus flavus - drug effects
Aspergillus flavus - growth & development
Aspergillus flavus - metabolism
Benzaldehydes - chemistry
Benzaldehydes - pharmacology
Cinnamomum zeylanicum - chemistry
Hemidesmus - chemistry
Molecular Structure
Plant Extracts - chemistry
Plant Extracts - pharmacology
Schiff Bases - chemistry
Schiff Bases - pharmacology
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Summary:2-Hydroxy-4-methoxybenzaldehyde (HMBA) is a nontoxic phenolic flavor from dietary source Decalipus hamiltonii and Hemidesmus indicus. HMBA is an excellent antimicrobial agent with additional antiaflatoxigenic potency. On the other hand, cinnamaldehyde from cinnamon is a widely employed flavor with significant antiaflatoxigenic activity. We have attempted the enhancement of antiaflatoxigenic and antimicrobial properties of HMBA, cinnamaldehyde, and similar molecules via Schiff base formation accomplished from condensation reaction with amino sugar (d-glucamine). HMBA derived Schiff bases exhibited commendable antiaflatoxigenic activity at the concentration 0.1 mg/mL resulting in 9.6 ± 1.9% growth of Aspergillus flavus and subsequent 91.4 ± 3.9% reduction of aflatoxin B1 with respect to control.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.7b02576