Rogersonins C-F, 9 H -Imidazo[2,1- i ]purine-Incorporating Adenine-Polyketide Hybrids from an Ophiocordyceps -Associated Clonostachys rogersoniana

Rogersonins C-F ( - ), four unprecedented adenine-polyketide hybrids featuring a rare 9 -imidazo[2,1- ]purine (1, -ethenoadenine) moiety, were isolated from an -associated fungus, . Their structures were elucidated primarily by NMR experiments. The absolute configurations of - were assigned by a com...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2024-06, Vol.87 (6), p.1618-1627
Main Authors: Hou, Xintong, Wang, Ruikun, Zhang, Chunyan, Xu, Yang, Zhu, Shuaiming, Zhang, Yang, Liu, Xingzhong, Che, Yongsheng
Format: Article
Language:English
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Summary:Rogersonins C-F ( - ), four unprecedented adenine-polyketide hybrids featuring a rare 9 -imidazo[2,1- ]purine (1, -ethenoadenine) moiety, were isolated from an -associated fungus, . Their structures were elucidated primarily by NMR experiments. The absolute configurations of - were assigned by a combination of the modified Mosher method, chemical degradation, electronic circular dichroism (ECD) calculations, and X-ray crystallography using Cu Kα radiation. Compound downregulated the expression of PD-L1 protein in MDA-MB-231 and A549 cells, but did not show detectable effect on mRNA transcription of the PD-L1-encoding gene .
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.4c00266