Synthesis of Polysubstituted Pyrimidines through Palladium-Catalyzed Isocyanide Insertion to 2 H -Azirines

The domino process of the palladium-catalyzed coupling reaction of isocyanides with 2 -azirine provides various tetrasubstituted pyrimidines via one C-C bond and two C-N bond formations with satisfactory yields. The title compounds are obtained with good functional group tolerance, high atom economy...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2023-09, Vol.88 (17), p.12519-12525
Main Authors: Saeifard, Leyla, Amiri, Kamran, Rominger, Frank, Müller, Thomas J J, Balalaie, Saeed
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The domino process of the palladium-catalyzed coupling reaction of isocyanides with 2 -azirine provides various tetrasubstituted pyrimidines via one C-C bond and two C-N bond formations with satisfactory yields. The title compounds are obtained with good functional group tolerance, high atom economy, and broad substrate scopes.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c01248