Palladium-Catalyzed [3 + 2] Cycloaddition of 4‑Vinyl-4-Butyrolactones with Alkenes: Synthesis of Spirocyclopentane Compounds

A palladium-catalyzed [3 + 2] cycloaddition of 4-vinyl-4-butyrolactones (VBLs) with alkenes has been developed to afford various spirocyclopentane products in high yields with excellent diastereoselectivities. The scale-up reaction and further derivations of the product worked well, demonstrating th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2024-10, Vol.89 (19), p.14141-14150
Main Authors: Sun, Honghao, Song, Aoran, Gu, Shuang, Tang, Yi, Yang, Sen, Li, Wenhui, Guo, Hongchao
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A palladium-catalyzed [3 + 2] cycloaddition of 4-vinyl-4-butyrolactones (VBLs) with alkenes has been developed to afford various spirocyclopentane products in high yields with excellent diastereoselectivities. The scale-up reaction and further derivations of the product worked well, demonstrating the potential application of the current reaction in organic synthesis.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.4c01532