Protein Self-Assembly at the Liquid–Surface Interface. Surface-Mediated Aggregation Catalysis

Protein self-assembly into aggregates of various morphologies is a ubiquitous phenomenon in physical chemistry and biophysics. The critical role of amyloid assemblies in the development of diseases, neurodegenerative diseases especially, highlights the importance of understanding the mechanistic pic...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2023-03, Vol.127 (9), p.1880-1889
Main Author: Lyubchenko, Yuri L.
Format: Article
Language:English
Subjects:
Amyloid - metabolism
Amyloid beta-Peptides - metabolism
Amyloidogenic Proteins
Computer Simulation
Humans
Neurodegenerative Diseases - metabolism
Protein Aggregation, Pathological
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Summary:Protein self-assembly into aggregates of various morphologies is a ubiquitous phenomenon in physical chemistry and biophysics. The critical role of amyloid assemblies in the development of diseases, neurodegenerative diseases especially, highlights the importance of understanding the mechanistic picture of the self-assembly process. The translation of this knowledge to the development of efficient preventions and treatments for diseases requires designing experiments at conditions mimicking those in vivo. This Perspective reviews data satisfying two major requirements: membrane environment and physiologically low concentrations of proteins. Recent progress in experiments and computational modeling resulted in a novel model for the amyloid aggregation process at the membrane–liquid interface. The self-assembly under such conditions has a number of critical features, further understanding of which can lead to the development of efficient preventive means and treatments for Alzheimer’s and other devastating neurodegenerative disorders.
ISSN:1520-6106
1520-5207
DOI:10.1021/acs.jpcb.2c09029