Scalable Synthesis of Single-Chain Nanoparticles under Mild Conditions

We present a scalable route to single-chain nanoparticles (SCNP) under mild conditions using intramolecular atom transfer radical coupling (ATRC). Typical methods to SCNP, a class of soft nanomaterials in the sub-10 nm size regime, rely on complicated synthetic techniques, high temperatures unsuitab...

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Bibliographic Details
Published in:Macromolecules 2017-04, Vol.50 (7), p.2996-3003
Main Authors: Hanlon, Ashley M, Chen, Ruiwen, Rodriguez, Kyle J, Willis, Claudia, Dickinson, Jessica G, Cashman, Mark, Berda, Erik B
Format: Article
Language:English
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Summary:We present a scalable route to single-chain nanoparticles (SCNP) under mild conditions using intramolecular atom transfer radical coupling (ATRC). Typical methods to SCNP, a class of soft nanomaterials in the sub-10 nm size regime, rely on complicated synthetic techniques, high temperatures unsuitable to fragile functional groups, or ultradilute conditions (solutions less than 1 wt %), all of which greatly complicate scale-up. Our method uses a minimal number of synthetic steps and mild reaction conditions amenable to a wide array of solvents and tolerant to a variety of functional groups. Using this scalable method, gram quantities of nanoparticles in the 5–10 nm size regime are accessible.
ISSN:0024-9297
1520-5835
DOI:10.1021/acs.macromol.7b00497