Well-Defined Biomimicking Brush-Polymer Self-Assemblies Revealing Cholesterol- and Phosphorylcholine-Enriched Surface

• Published in: Macromolecules 2017-09, Vol.50 (17), p.6489-6500
• Main Authors: Kim, Changsub, Kwon, Kyungho, Lee, Jongchan, Kim, Heesoo, Chae, Keun-Hwa, Ree, Moonhor
• Format: Article
• Language: English
• ISSN: 0024-9297; 1520-5835
• DOI: 10.1021/acs.macromol.7b00805

We have newly synthesized a series of well-defined brush polyethers bearing cholesterol (Chol) and phosphorylcholine (PC) moieties in various compositions which can mimic cell membrane. They were thermally stable up to at least 230 °C and soluble in common solvents, showing good solution processability. Excitingly, they all favorably self-assembled, forming multibilayer structures with 21 chain conformation; in comparison, the brush polyether bearing only PC-bristles formed orthorhombically packed cylinder (OPC) structure with 125 helical chain conformation. Such multibilayer structure formations could be driven by a strong self-assembling ability of the Chol-bristle in extended conformation; the multibilayer structure formation was further promoted by the presence of PC-bristles. The OPC structure formation could be driven by a lateral packing ability of the brush polymer chain in the helical confirmation resulted from the minimization of repulsive interactions in the neighbored zwitterionic PC-bristles. Because of such the self-assembling natures, all brush polymers always revealed Chol- and PC-enriched surface. Overall, all brush polyethers of this study successfully mimicked cell membrane features (Chol- and PC-surface based on self-assembling). They are very suitable for uses in the fields required cell membrane surface characteristics.