Dimethyl Fumarate: Heterogeneous Catalysis for the Development of an Innovative Flow Synthesis

The present work describes the development of an improved synthesis of the active pharmaceutical ingredient (API) dimethyl fumarate. The use of continuous flow technology and the newly developed methylation conditions solve some of the issues of previous commercial production strategies, e.g., reach...

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Bibliographic Details
Published in:Organic process research & development 2021-02, Vol.25 (2), p.292-299
Main Authors: Dedè, Fabiana, Piccolo, Oreste, Vigo, Daniele
Format: Article
Language:English
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Summary:The present work describes the development of an improved synthesis of the active pharmaceutical ingredient (API) dimethyl fumarate. The use of continuous flow technology and the newly developed methylation conditions solve some of the issues of previous commercial production strategies, e.g., reaching complete conversion and avoiding the formation of toxic impurities. The optimization was carried out using the design of experiment approach and afforded a very efficient, sustainable process, suitable for the industrial application.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.0c00503