Controlled Flow Precipitation as a Valuable Tool for Synthesis

In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an important area of research. In this arti...

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Bibliographic Details
Published in:Organic process research & development 2016-02, Vol.20 (2), p.371-375
Main Authors: Filipponi, Paolo, Gioiello, Antimo, Baxendale, Ian R
Format: Article
Language:English
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Summary:In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an important area of research. In this article we demonstrate how a dynamically agitated flow reactor can be a powerful tool to facilitate workup and processing of biphasic solid–liquid flow streams at scale.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.5b00331