Improved Synthesis of Unsymmetrical Carbonate Derivatives Using Calcium Salts

An effective synthetic method for unsymmetrical carbonate species has been developed. Calcium oxide and calcium hydroxide were found to be highly effective for this reaction, affording unsymmetrical carbonates in high yield and purity. Calcium chloride, which is a coproduct, serves as a water scaven...

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Bibliographic Details
Published in:Organic process research & development 2019-04, Vol.23 (4), p.667-673
Main Authors: Hamada, Tomohito, Okada, Michiaki, Yamauchi, Akiyoshi, Kishikawa, Yosuke
Format: Article
Language:English
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Summary:An effective synthetic method for unsymmetrical carbonate species has been developed. Calcium oxide and calcium hydroxide were found to be highly effective for this reaction, affording unsymmetrical carbonates in high yield and purity. Calcium chloride, which is a coproduct, serves as a water scavenger that can be easily removed. Additional drying processes and complicated purification steps are not necessary in this reaction. This improved process is important in terms of green sustainable chemistry principles.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.9b00087