Ligand-Controlled Stereoselective Synthesis of Heterotactic Polylactide with Titanium(IV) Complexes

Stereoselective synthesis of polylactic acid (PLA) was achieved using titanium­(IV) complexes. The NO3 ligands prepared from 2,2′-dihydroxybenzophenone and salicylaldehyde derivatives were used to control the stereoselectivity of Ti­(IV)-catalyzed polymerization of rac-lactide, in which a substitute...

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Bibliographic Details
Published in:Organometallics 2022-02, Vol.41 (3), p.328-334
Main Authors: Jeong, Yeolib, Shin, Minjoong, Seo, Myungeun, Kim, Hyunwoo
Format: Article
Language:English
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Summary:Stereoselective synthesis of polylactic acid (PLA) was achieved using titanium­(IV) complexes. The NO3 ligands prepared from 2,2′-dihydroxybenzophenone and salicylaldehyde derivatives were used to control the stereoselectivity of Ti­(IV)-catalyzed polymerization of rac-lactide, in which a substituted ligand provided heterotactic PLA with high stereoselectivity. Density functional theory calculations revealed that the ligand structure is crucial for differentiating reaction pathways, and that the octahedral transition states are stabilized by the preorganized intermediates.
ISSN:0276-7333
1520-6041
DOI:10.1021/acs.organomet.1c00666