Photoredox-Catalysis Fluorosulfonyldifluoromethylation of Unactivated Alkenes and (Hetero)arenes with ICF 2 SO 2 F

The fluorosulfonyldifluoromethylation of unactivated alkenes and (hetero)arenes with iododifluoromethanesulfonyl fluoride (ICF SO F) under visible light photoredox catalysis was successfully developed. Key to the successful fluorosulfonyldifluoromethylation of aromatic compounds was the usage of AgO...

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Bibliographic Details
Published in:Organic letters 2024-08, Vol.26 (32), p.6900-6904
Main Authors: He, Xu-Biao, Jia, Xin, Zhao, Pin-Qiao, Fang, Zeguo, Qing, Feng-Ling
Format: Article
Language:English
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Summary:The fluorosulfonyldifluoromethylation of unactivated alkenes and (hetero)arenes with iododifluoromethanesulfonyl fluoride (ICF SO F) under visible light photoredox catalysis was successfully developed. Key to the successful fluorosulfonyldifluoromethylation of aromatic compounds was the usage of AgOTf as an additive to promote the formation of the CF SO F radical. The protocol provided a straightforward way to introduce the interesting and useful CF SO F group on sp and sp carbons.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.4c02538