Decarboxylative Borylation of m CPBA-Activated Aliphatic Acids

A decarboxylative borylation of aliphatic acids for the synthesis of a variety of alkylboronates has been developed by mixing -chloroperoxybenzoic acid ( CPBA)-activated fatty acids with bis(catecholato)diboron in , -dimethylformamide (DMF) at room temperature. A radical chain process is involved in...

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Bibliographic Details
Published in:Organic letters 2020-01, Vol.22 (1), p.234-238
Main Authors: Wei, Dian, Liu, Tu-Ming, Zhou, Bo, Han, Bing
Format: Article
Language:English
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Summary:A decarboxylative borylation of aliphatic acids for the synthesis of a variety of alkylboronates has been developed by mixing -chloroperoxybenzoic acid ( CPBA)-activated fatty acids with bis(catecholato)diboron in , -dimethylformamide (DMF) at room temperature. A radical chain process is involved in the reaction which initiates from the B-B bond homolysis followed by the radical transfer from the boron atom to the carbon atom with subsequent decarboxylation and borylation.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b04218