Titanium-Based Alloy Surface Modification with TiO 2 and Poly(sodium 4-styrenesulfonate) Multilayers for Dental Implants

• Published in: ACS applied bio materials 2021-04, Vol.4 (4), p.3055-3066
• Main Authors: Kitagawa, Igor L, Miyazaki, Celina M, Pitol-Palin, Letícia, Okamoto, Roberta, de Vasconcellos, Luana M R, Constantino, Carlos J L, Lisboa-Filho, Paulo N
• Format: Article
• Language: English
• Subjects: Alloys - chemistry; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Dental Implants; Materials Testing; Particle Size; Polystyrenes - chemistry; Titanium - chemistry
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.0c01348

Implant placement is an important repair method in dentistry and orthopedics. Increasing efforts have focused on optimizing the biocompatibility and osseointegration properties of titanium (Ti) and Ti-based alloys. In this work, Ti-based alloys were modified by the layer-by-layer (LbL) technique, which is a simple and versatile method for surface modification. The morphology and chemical structure of LbL films of poly(sodium 4-styrenesulfonate) (PSS) and Ti dioxide (TiO ) nanoparticles were first characterized employing ultraviolet-visible and Fourier-transform infrared spectroscopies as well as atomic force microscopy for further application in Ti-based alloy implants. The changes provoked by the LbL PSS/TiO film on the Ti-based alloy surfaces were then investigated by scanning electron microscopy and micro-Raman techniques. Finally, in vivo tests (immunolabeling and biomechanical analysis) performed with screw implants in rats suggested that PSS/TiO multilayers promote changes in both topography and chemical surface properties of the screw, providing beneficial effects for osteoblast activity. This simple and relatively low-cost growth process can open up possibilities to improve dental implants and, probably, bone implants in general.