Loading…

Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification

Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However...

Full description

Saved in:
Bibliographic Details
Published in:ACS applied bio materials 2021-08, Vol.4 (8), p.6046-6055
Main Authors: Yun, Jinyoung, Jeong, Yeonsu, Nam, Onyou, Yeo, Ki Baek, Jo, Yun Kee, Heo, Hye Ryoung, Kim, Chang Sup, Joo, Kye Il, Pack, Seung Pil, Jin, EonSeon, Cha, Hyung Joon
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However, there are still no alternatives that can completely replace the existing animal-derived bone graft materials. In this work, a marine-inspired biomineral complex was suggested as a potential bone graft material. The proposed biosilicified coccolithophore-derived coccoliths using bioengineered mussel adhesive proteins show osteopromotive ability through the synergistic effects of osteoconductivity from calcium carbonate and osteoinductivity from silica. Its possibility of use as a bone substitute was determined by evaluating the in vitro osteogenic behaviors of multipotent mesenchymal stem cells and in vivo bone regeneration in a rat calvarial defect model. Therefore, the marine-inspired biomineral complex developed in this study could be successfully used for bone tissue engineering.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.1c00346