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The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment

Magnetic hyperthermia is a cancer treatment based on the exposure of magnetic nanoparticles to an alternating magnetic field in order to generate local heat. In this work, 3D cell culture models were prepared to observe the effect that a different number of internalized particles had on the mechanis...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2020-09, Vol.12 (39), p.43474-43487
Main Authors: Beola, Lilianne, Asín, Laura, Roma-Rodrigues, Catarina, Fernández-Afonso, Yilian, Fratila, Raluca M, Serantes, David, Ruta, Sergiu, Chantrell, Roy W, Fernandes, Alexandra R, Baptista, Pedro V, de la Fuente, Jesús M, Grazú, Valeria, Gutiérrez, Lucía
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Language:English
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Summary:Magnetic hyperthermia is a cancer treatment based on the exposure of magnetic nanoparticles to an alternating magnetic field in order to generate local heat. In this work, 3D cell culture models were prepared to observe the effect that a different number of internalized particles had on the mechanisms of cell death triggered upon the magnetic hyperthermia treatment. Macrophages were selected by their high capacity to uptake nanoparticles. Intracellular nanoparticle concentrations up to 7.5 pg Fe/cell were measured both by elemental analysis and magnetic characterization techniques. Cell viability after the magnetic hyperthermia treatment was decreased to
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.0c12900