Amphiphilic Alginate-Based Layer-by-Layer Coatings Exhibiting Resistance against Nonspecific Protein Adsorption and Marine Biofouling

Amphiphilic coatings are promising materials for fouling-release applications, especially when their building blocks are inexpensive, biodegradable, and readily accessible poly­saccharides. Here, amphiphilic polysaccharides were fabricated by coupling hydrophobic pentafluoropropylamine (PFPA) to car...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2022-04, Vol.14 (14), p.16062-16073
Main Authors: Gnanasampanthan, Thuvarakhan, Karthäuser, Jana F, Spöllmann, Stephan, Wanka, Robin, Becker, Hans-Werner, Rosenhahn, Axel
Format: Article
Language:English
Subjects:
Adsorption
Alginates
Alginic Acid
Biofouling - prevention & control
Biological and Medical Applications of Materials and Interfaces
Diatoms
Excipients
Polysaccharides
Surface Properties
Water
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Summary:Amphiphilic coatings are promising materials for fouling-release applications, especially when their building blocks are inexpensive, biodegradable, and readily accessible poly­saccharides. Here, amphiphilic polysaccharides were fabricated by coupling hydrophobic pentafluoropropylamine (PFPA) to carboxylate groups of hydrophilic alginic acid, a natural biopolymer with high water-binding capacity. Layer-by-layer (LbL) coatings comprising unmodified or amphiphilic alginic acid (AA*) and poly­ethyl­enimine (PEI) were assembled to explore how different PFPA contents affect their physicochemical properties, resistance against nonspecific adsorption (NSA) of proteins, and antifouling activity against marine bacteria (Cobetia marina) and diatoms (Navicula perminuta). The amphiphilic multilayers, characterized through spectroscopic ellipsometry, water contact angle goniometry, elemental analysis, AFM, XPS, and SPR spectroscopy, showed similar or even higher swelling in water and exhibited higher resistance toward NSA of proteins and microfouling marine organisms than multilayers without fluoroalkyl groups.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.2c01809