Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems

A new strategy for creating functional trilayer nanofibers through triaxial electrospinning is demonstrated. Ethyl cellulose (EC) was used as the filament-forming matrix in the outer, middle, and inner working solutions and was combined with varied contents of the model active ingredient ketoprofen...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2015-08, Vol.7 (33), p.18891-18897
Main Authors: Yu, Deng-Guang, Li, Xiao-Yan, Wang, Xia, Yang, Jun-He, Bligh, S. W. Annie, Williams, Gareth R
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - metabolism
Cellulose - analogs & derivatives
Cellulose - chemistry
Drug Carriers - chemistry
Drug Liberation
Ketoprofen - chemistry
Ketoprofen - metabolism
Nanofibers - chemistry
Nanofibers - ultrastructure
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Summary:A new strategy for creating functional trilayer nanofibers through triaxial electrospinning is demonstrated. Ethyl cellulose (EC) was used as the filament-forming matrix in the outer, middle, and inner working solutions and was combined with varied contents of the model active ingredient ketoprofen (KET) in the three fluids. Triaxial electrospinning was successfully carried out to generate medicated nanofibers. The resultant nanofibers had diameters of 0.74 ± 0.06 μm, linear morphologies, smooth surfaces, and clear trilayer nanostructures. The KET concentration in each layer gradually increased from the outer to the inner layer. In vitro dissolution tests demonstrated that the nanofibers could provide linear release of KET over 20 h. The protocol reported in this study thus provides a facile approach to creating functional nanofibers with sophisticated structural features.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.5b06007