Sustained Release of BMP‑2 from Porous Particles with Leaf-Stacked Structure for Bone Regeneration

Sustained release of bioactive molecules from delivery systems is a common strategy for ensuring their prolonged bioactivity and for minimizing safety issues. However, residual toxic reagents, the use of harsh organic solvents, and complex fabrication procedures in conventional delivery systems are...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2018-06, Vol.10 (25), p.21091-21102
Main Authors: Kim, Ho Yong, Lee, Jin Ho, Lee, Han A Reum, Park, Ji-Sung, Woo, Dong Kyun, Lee, Hee-Chun, Rho, Gyu-Jin, Byun, June-Ho, Oh, Se Heang
Format: Article
Language:English
Subjects:
Bone Morphogenetic Protein 2
Bone Regeneration
Delayed-Action Preparations
Humans
Osteogenesis
Periosteum
Porosity
Tissue Scaffolds
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Summary:Sustained release of bioactive molecules from delivery systems is a common strategy for ensuring their prolonged bioactivity and for minimizing safety issues. However, residual toxic reagents, the use of harsh organic solvents, and complex fabrication procedures in conventional delivery systems are considered enormous impediments toward clinical use. Herein, we describe bone morphogenetic protein-2 (BMP-2)-immobilized porous polycaprolactone particles with unique leaf-stacked structures (LSS particles) prepared using clinically feasible materials and procedures. The BMP-2 immobilized in these LSS particles is continuously released up to 36 days to provide an appropriate environment for osteogenic differentiation of human periosteum-derived cells and new bone formation. Thus, the leaf-stacked structures of these LSS particles provide a simple but clinically applicable platform for effectively delivering a variety of bioactive molecules, such as growth factors, hormones, cytokines, peptides, etc.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.8b02141