Highly Efficient Vacancy-Driven Photothermal Therapy Mediated by Ultrathin MnO 2 Nanosheets

In medical applications, two-dimensional nanomaterials have been widely studied on account of their intriguing properties such as good biocompatibility, stability, and multifunctionality. Herein, an ultrathin MnO nanosheet has been fabricated by a simplistic hydrothermal process. The high phototherm...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2019-02, Vol.11 (6), p.6267-6275
Main Authors: Wang, Li, Guan, Shanyue, Weng, Yangziwan, Xu, Si-Min, Lu, Heng, Meng, Xiangmin, Zhou, Shuyun
Format: Article
Language:English
Subjects:
Animals
Cell Survival - drug effects
HeLa Cells
Humans
Hydrogen Peroxide - chemistry
Infrared Rays
Manganese Compounds - chemistry
Manganese Compounds - therapeutic use
Mice
Nanostructures - chemistry
Nanostructures - toxicity
Neoplasms - drug therapy
Neoplasms - pathology
Neoplasms - therapy
Oxides - chemistry
Oxides - therapeutic use
Phototherapy
Transplantation, Heterologous
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Summary:In medical applications, two-dimensional nanomaterials have been widely studied on account of their intriguing properties such as good biocompatibility, stability, and multifunctionality. Herein, an ultrathin MnO nanosheet has been fabricated by a simplistic hydrothermal process. The high photothermal conversion performance (62.4%) can be attributed to the vacancy in the ultrathin MnO nanosheet, as confirmed by the extended X-ray absorption fine structure results and the density functional theory calculation, benefiting photoacoustic imaging-guided cancer therapy. This highly efficient vacancy-induced photothermal therapy has been reported for the first time. As a result, this work demonstrates that this ultrathin MnO nanosheet has a potential to construct a nanosystem for imaging-guided cancer therapy.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.8b20639