Gold-Catalyzed 1,2-Aminoarylation of Alkenes with External Amines

Reported herein is the gold-catalyzed 1,2-aminoarylation of alkenes that engages external amine as a coupling partner. Careful optimization studies revealed a significant role of the concentration of base to achieve highly chemoselective access to the aminoarylation products over potential C–N cross...

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Bibliographic Details
Published in:ACS catalysis 2021-04, Vol.11 (8), p.4576-4582
Main Authors: Tathe, Akash G, Urvashi, Yadav, Amit K, Chintawar, Chetan C, Patil, Nitin T
Format: Article
Language:English
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Summary:Reported herein is the gold-catalyzed 1,2-aminoarylation of alkenes that engages external amine as a coupling partner. Careful optimization studies revealed a significant role of the concentration of base to achieve highly chemoselective access to the aminoarylation products over potential C–N cross-coupled products. Overcoming all the limitations, the current strategy provided straightforward access to the medicinally relevant 3-aminochroman, 2-aminotetra­hydro­naphthalene, and 2-aminoindane derivatives.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.1c00789