Nickel-Catalyzed Enantioselective Addition of Styrenes to Cyclic N‑Sulfonyl α‑Ketiminoesters

Enantioselective addition of styrenes to cyclic N-sulfonyl α-ketiminoesters was developed using the complex of Ni­(ClO4)2 with chiral phosphine complex as a catalyst. A range of chiral benzofused 5-membered sultams bearing alkenylated or allylated α-tetrasubstituted amino ester framework were afford...

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Bibliographic Details
Published in:ACS catalysis 2015-11, Vol.5 (11), p.6524-6528
Main Authors: Liu, Ren-Rong, Wang, Dan-Jie, Wu, Liang, Xiang, Bin, Zhang, Guo-Qi, Gao, Jian-Rong, Jia, Yi-Xia
Format: Article
Language:English
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Summary:Enantioselective addition of styrenes to cyclic N-sulfonyl α-ketiminoesters was developed using the complex of Ni­(ClO4)2 with chiral phosphine complex as a catalyst. A range of chiral benzofused 5-membered sultams bearing alkenylated or allylated α-tetrasubstituted amino ester framework were afforded in excellent enantioselectivities (up to 99% ee) as potential biologically active compounds for drug research.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.5b01793