Visible-Light-Promoted Atom Transfer Radical Cyclization of Unactivated Alkyl Iodides

A visible-light-mediated atom transfer radical cyclization of unactivated alkyl iodides is described. This protocol operates under mild conditions and exhibits high chemoselectivity profile while avoiding parasitic hydrogen atom transfer pathways. Preliminary mechanistic studies challenge the percep...

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Bibliographic Details
Published in:ACS catalysis 2017-01, Vol.7 (1), p.409-412
Main Authors: Shen, Yangyang, Cornella, Josep, Juliá-Hernández, Francisco, Martin, Ruben
Format: Article
Language:English
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Summary:A visible-light-mediated atom transfer radical cyclization of unactivated alkyl iodides is described. This protocol operates under mild conditions and exhibits high chemoselectivity profile while avoiding parasitic hydrogen atom transfer pathways. Preliminary mechanistic studies challenge the perception that a canonical photoredox catalytic cycle is being operative.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.6b03205