Manganese-Catalyzed Direct Deoxygenation of Primary Alcohols

Deoxygenation of alcohols is an important tool in the repertoire of defunctionalization methods in modern synthetic chemistry. We report the base-metal-catalyzed direct deoxygenation of benzylic and aliphatic primary alcohols via oxidative dehydrogenation/Wolff–Kishner reduction. The reaction is cat...

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Bibliographic Details
Published in:ACS catalysis 2017-07, Vol.7 (7), p.4462-4466
Main Authors: Bauer, Jonathan O, Chakraborty, Subrata, Milstein, David
Format: Article
Language:English
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Summary:Deoxygenation of alcohols is an important tool in the repertoire of defunctionalization methods in modern synthetic chemistry. We report the base-metal-catalyzed direct deoxygenation of benzylic and aliphatic primary alcohols via oxidative dehydrogenation/Wolff–Kishner reduction. The reaction is catalyzed by a well-defined PNP pincer complex of Earth-abundant manganese, evolving H2, N2, and water as the only byproducts.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.7b01729