Catalyst-Controlled Stereoselective Synthesis of Atropisomers

Owing to their favorable molecular topology, atropisomers represent particularly valuable chiral scaffolds for numerous applications throughout academic research and industry. Nevertheless, whereas various well-established catalyst-controlled methodologies allow addressing stereocenter configuration...

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Bibliographic Details
Published in:ACS catalysis 2018-04, Vol.8 (4), p.2981-2988
Main Authors: Zilate, Bouthayna, Castrogiovanni, Alessandro, Sparr, Christof
Format: Article
Language:English
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Summary:Owing to their favorable molecular topology, atropisomers represent particularly valuable chiral scaffolds for numerous applications throughout academic research and industry. Nevertheless, whereas various well-established catalyst-controlled methodologies allow addressing stereocenter configuration, efficient procedures to prepare axially chiral compounds in high isomeric purity are still scarce. Complementary to the comprehensive reviews in the area, this Perspective features representative advances for the catalyst-stereocontrolled synthesis of atropisomeric scaffolds. With a focus on axially chiral motifs frequently utilized in catalysis or medicinal chemistry, selected recent examples encompassing unique stereoselective transition metal, hydrogen bond, ion pairing, chiral phosphoric acid, and amine catalysis are highlighted.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.7b04337