Ni/Ti Dual Catalytic Cross-Coupling of Nitriles and Organobromides To Access Ketones

Herein, we report the development of a dual catalytic approach for the cross-coupling of nitriles with aryl- and aliphatic-bromides. A titanium­(III) catalyst is used to activate nitriles enabling their coupling with organobromides through a nickel catalyst. The Ni/Ti system efficiently prepared uns...

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Bibliographic Details
Published in:ACS catalysis 2018-05, Vol.8 (5), p.4539-4544
Main Authors: Chenniappan, Vinoth Kumar, Silwal, Sajan, Rahaim, Ronald J
Format: Article
Language:English
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Summary:Herein, we report the development of a dual catalytic approach for the cross-coupling of nitriles with aryl- and aliphatic-bromides. A titanium­(III) catalyst is used to activate nitriles enabling their coupling with organobromides through a nickel catalyst. The Ni/Ti system efficiently prepared unsymmetrical ketones with good chemoselectivity and could selectively couple a bromide in the presence of other functionalizable handles.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.8b00244