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Radical-Organometallic Hybrid Reaction System Enabling Couplings between Tertiary-Alkyl Groups and 1‑Alkenyl Groups

Suzuki–Miyaura couplings of tertiary-alkyl moieties are accomplished in the presence of a copper catalyst, in which quaternary carbons possessing various functional groups can be synthesized via a radical reaction. Mechanistic studies revealed that 1-alkenylcopperI plays an important role in this co...

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Bibliographic Details
Published in:ACS catalysis 2018-08, Vol.8 (8), p.6791-6795
Main Authors: Nakamura, Kimiaki, Hara, Reina, Sunada, Yusuke, Nishikata, Takashi
Format: Article
Language:English
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Summary:Suzuki–Miyaura couplings of tertiary-alkyl moieties are accomplished in the presence of a copper catalyst, in which quaternary carbons possessing various functional groups can be synthesized via a radical reaction. Mechanistic studies revealed that 1-alkenylcopperI plays an important role in this coupling reaction. We expect that the radical-organometallic combined process will become one of the best options for the synthesis of quaternary carbons.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.8b01572