Interplay between Mitophagy and Inflammasomes in Neurological Disorders

Mitophagy and inflammasomes have a pivotal role in the development of neuropathology. Molecular mechanisms behind mitophagy and inflammasomes are well-understood, but lacunae prevail in understanding the crosstalk between them in various neurological disorders. As mitochondrial dysfunction is the pr...

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Published in:ACS chemical neuroscience 2019-05, Vol.10 (5), p.2195-2208
Main Authors: Kesharwani, Radhika, Sarmah, Deepaneeta, Kaur, Harpreet, Mounika, Leela, Verma, Geetesh, Pabbala, Veeresh, Kotian, Vignesh, Kalia, Kiran, Borah, Anupom, Dave, Kunjan R, Yavagal, Dileep R, Bhattacharya, Pallab
Format: Article
Language:English
Subjects:
Animals
Autophagy - physiology
Brain - metabolism
Brain - pathology
Humans
Inflammasomes - metabolism
Mitochondria - metabolism
Mitophagy - physiology
Nervous System Diseases - metabolism
Nervous System Diseases - pathology
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Summary:Mitophagy and inflammasomes have a pivotal role in the development of neuropathology. Molecular mechanisms behind mitophagy and inflammasomes are well-understood, but lacunae prevail in understanding the crosstalk between them in various neurological disorders. As mitochondrial dysfunction is the prime event in neurodegeneration, the clearance of impaired mitochondria is one of the main tasks for maintaining cell integrity in the majority of neuropathologies. Along with it, inflammasome activation also plays a major role, which is usually followed by mitochondrial dysfunction. The present review highlights basics of autophagy, mitophagy, and inflammasomes and the molecular mechanisms involved, and more importantly, it tries to elaborate the interplay between mitophagy and inflammasomes in various neurological disorders. This will help in upgrading the reader’s understanding in exploring the link between mitophagy and inflammasomes, which has dealt with limitations in past studies.
ISSN:1948-7193
1948-7193
DOI:10.1021/acschemneuro.9b00117