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FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry
DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO N as the diazo-transfer reagent in solution. This reaction demonstrates high...
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Published in: | ACS medicinal chemistry letters 2024-09, Vol.15 (9), p.1591-1597 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO
N
as the diazo-transfer reagent in solution. This reaction demonstrates high conversions and facile operation while being metal-free and maintaining high levels of DNA fidelity. It is also compatible with a wide range of substrates, allowing for convenient access to both aliphatic and aromatic amines. Consequently, it will further enrich the DEL chemistry toolbox. |
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ISSN: | 1948-5875 1948-5875 |
DOI: | 10.1021/acsmedchemlett.4c00307 |