Environmentally Adaptive Shape-Morphing Microrobots for Localized Cancer Cell Treatment

• Published in: ACS nano 2021-11, Vol.15 (11), p.18048-18059
• Main Authors: Xin, Chen, Jin, Dongdong, Hu, Yanlei, Yang, Liang, Li, Rui, Wang, Li, Ren, Zhongguo, Wang, Dawei, Ji, Shengyun, Hu, Kai, Pan, Deng, Wu, Hao, Zhu, Wulin, Shen, Zuojun, Wang, Yucai, Li, Jiawen, Zhang, Li, Wu, Dong, Chu, Jiaru
• Format: Article
• Language: English
• Subjects: Doxorubicin - pharmacology; Drug Delivery Systems - methods; Drug Liberation; HeLa Cells; Humans; Neoplasms - drug therapy; Robotics
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.1c06651

Microrobots have attracted considerable attention due to their extensive applications in microobject manipulation and targeted drug delivery. To realize more complex micro-/nanocargo manipulation (e.g., encapsulation and release) in biological applications, it is highly desirable to endow microrobots with a shape-morphing adaptation to dynamic environments. Here, environmentally adaptive shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rates in a pH-responsive hydrogel. Due to a combination with magnetic propulsion, a shape-morphing microcrab (SMMC) is able to perform targeted microparticle delivery, including gripping, transporting, and releasing by “opening–closing” of a claw. As a proof-of-concept demonstration, a shape-morphing microfish (SMMF) is designed to encapsulate a drug (doxorubicin (DOX)) by closing its mouth in phosphate-buffered saline (PBS, pH ∼ 7.4) and release the drug by opening its mouth in a slightly acidic solution (pH < 7). Furthermore, localized HeLa cell treatment in an artificial vascular network is realized by “opening–closing” of the SMMF mouth. With the continuous optimization of size, motion control, and imaging technology, these magnetic SMMRs will provide ideal platforms for complex microcargo operations and on-demand drug release.