Terrylenediimide-Based Intrinsic Theranostic Nanomedicines with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Cancer Therapy

Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential cli...

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Bibliographic Details
Published in:ACS nano 2017-04, Vol.11 (4), p.3797-3805
Main Authors: Zhang, Shaobo, Guo, Weisheng, Wei, Jie, Li, Chan, Liang, Xing-Jie, Yin, Meizhen
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - drug therapy
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
Humans
Imides - chemistry
Imides - therapeutic use
Lasers
MCF-7 Cells
Mice
Photoacoustic Techniques
Phototherapy
Structure-Activity Relationship
Theranostic Nanomedicine
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Summary:Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. Herein, we demonstrated a terrylenediimide (TDI)-poly­(acrylic acid) (TPA)-based nanomedicine (TNM) platform used as an intrinsic theranostic agent. As an exploratory paradigm in seeking biomedical applications, TDI was modified with poly­(acrylic acid)­s (PAAs), resulting in eight-armed, star-like TPAs composed of an outside hydrophilic PAA corona and an inner hydrophobic TDI core. TNMs were readily fabricated via spontaneous self-assembly. Without additional vehicle and cargo, the as-prepared TNMs possessed a robust nanostructure and high photothermal conversion efficiency up to approximately 41%. The intrinsic theranostic properties of TNMs for use in photoacoustic (PA) imaging by a multispectral optoacoustic tomography system and in mediating photoinduced tumor ablation were intensely explored. Our results suggested that the TNMs could be successfully exploited as intrinsic theranostic agents for PA imaging-guided efficient tumor PTT. Thus, these TNMs hold great potential for (pre)­clinical translational development.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.6b08720