Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy

Second near-infrared (NIR-II, 1000–1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for in vivo photoinduced imaging and simultaneous therapy, as well as the long-term...

Full description

Saved in:
Bibliographic Details
Published in:ACS nano 2018-11, Vol.12 (11), p.11282-11293
Main Authors: Alifu, Nuernisha, Zebibula, Abudureheman, Qi, Ji, Zhang, Hequn, Sun, Chaowei, Yu, Xiaoming, Xue, Dingwei, Lam, Jacky W. Y., Li, Gonghui, Qian, Jun, Tang, Ben Zhong
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation - drug effects
Cell Tracking - methods
Drug Screening Assays, Antitumor
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacology
Humans
Infrared Rays
Male
Mice
Mice, Inbred ICR
Mice, Nude
Nanoparticles - chemistry
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - pathology
Optical Imaging
Phototherapy
Theranostic Nanomedicine
Urinary Bladder Neoplasms - diagnostic imaging
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Second near-infrared (NIR-II, 1000–1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for in vivo photoinduced imaging and simultaneous therapy, as well as the long-term tracing of specific biological objects, are still very rare. Herein we designed a single-molecular and NIR-II-emissive theranostic system by encapsulating a kind of aggregation-induced emission luminogen (AIEgen, named BPN-BBTD) with amphiphilic polymer. The ultra-stable BPN-BBTD nanoparticles were employed for the NIR-II fluorescence imaging and photothermal therapy of bladder tumors in vivo. The 785 nm excitation triggered photothermal therapy could completely eradicate the subcutaneous tumor and inhibit the growth of orthotopic tumors. Furthermore, BPN-BBTD nanoparticles were capable of monitoring subcutaneous and orthotopic tumors for a long time (32 days). Single-molecular and NIR-II-emitted aggregation-induced emission nanoparticles hold potential for the diagnosis, precise treatment, and metastasis monitoring of tumors in the future.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.8b05937