Photothermally Modulatable and Structurally Disintegratable Sub-8-nm Au 1 Ag 9 Embedded Nanoblocks for Combination Cancer Therapy Produced by Plug-in Assembly

• Published in: ACS nano 2020-09, Vol.14 (9), p.11040-11054
• Main Authors: Poudel, Kishwor, Park, Sungjae, Hwang, Jungho, Ku, Sae Kwang, Yong, Chul Soon, Kim, Jong Oh, Byeon, Jeong Hoon
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - therapeutic use; Humans; Nanomedicine; Neoplasms - drug therapy; Phototherapy; Silver - therapeutic use
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.9b09731

As well as the exploration of translatable delivery nanosystems for cancer therapeutic agents, the development of automatable continuous-flow manufacturing technology comprising digitally controlled reactions for the on-demand production of pharmaceuticals is an important challenge in anticancer nanomedicine. Most attempts to resolve these issues have involved the development of alternative reactions, formulations, or constructs containing stimulus components aimed at producing multiple approaches for highly efficacious combination cancer therapies. However, there has been no report of a platform based on plug-in execution that enables continuous-flow manufacture in a compact, reconfigurable manner, although an optimal platform technology may be a prerequisite for the timely translation of recently developed nanomedicines. To this end, we describe the development of a platform toward digitizable, continuous manufacture by a serial combination of plug-in reactionwares (heating plates, a spraying cup, and a photochamber) for single-pass flow fabrication. Specifically, we fabricated three different composite nanoblocks consisting of Au Ag (