Ultrasound-Enhanced Chemo-Photodynamic Combination Therapy by Using Albumin “Nanoglue”-Based Nanotheranostics

The combination of photodynamic therapy (PDT) and chemotherapy is considered to enhance the antitumor immunity and combat multidrug resistance. Some preclinical studies have reported a positive therapeutic outcome of using ultrasound (US) irradiation to enhance chemotherapy, but the combination of t...

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Bibliographic Details
Published in:ACS nano 2020-05, Vol.14 (5), p.5560-5569
Main Authors: Zhang, Yifan, Wan, Yilin, Chen, Yantao, Blum, Nicholas Thomas, Lin, Jing, Huang, Peng
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Humans
Paclitaxel - therapeutic use
Photochemotherapy
Photosensitizing Agents
Porphyrins
Theranostic Nanomedicine
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Summary:The combination of photodynamic therapy (PDT) and chemotherapy is considered to enhance the antitumor immunity and combat multidrug resistance. Some preclinical studies have reported a positive therapeutic outcome of using ultrasound (US) irradiation to enhance chemotherapy, but the combination of these three modalities has yet to be investigated. On the basis of the discovery of a strong affinity between a photosensitizer sinoporphyrin sodium (DVDMS) and human serum albumin (HSA), a clinically used albumin-paclitaxel (HSA-PTX) nanoparticle is utilized as a “nanoglue” to load a large amount of DVDMS by simple mixing. The five conformations of HSA and DVDMS with highest affinity were calculated using AutoDock Vina. The obtained albumin “nanoglue”-based nanotheranostics, HSA-PTX-DVDMS (HPD), has better fluorescence imaging and PDT performance than free DVDMS, probably due to the reduced quenching of DVDMS after dispersion in albumin. An efficacious tumor-targeting enhancement of chemotherapy by US irradiation is verified in a bilateral subcutaneous 4T1 tumors model. With the aid of US irradiation, the combined PDT and chemotherapy mediated by HPD achieve effective tumor growth inhibition. Overall, this “nanoglue”-based nanotheranostics is composed of several clinically used elements and integrates three clinical modalities with application prospects in clinic.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.9b09827